Mutational dynamics of SARS-CoV-2 in Austria
Andreas Bergthaler | Center for Molecular Medicine (CeMM)
(in collaboration with: Medical University of Vienna; Austian Agency for Health and Food Safety Ltd. (AGES) and other Austrian universities)
If you have any questions about the Call and the WWTF, please contact Michael Stampfer.
(in collaboration with: Medical University of Vienna; Austian Agency for Health and Food Safety Ltd. (AGES) and other Austrian universities)
(in collaboration with: Oliver H. Robak, Medical Univeristy of Vienna; Christoph Steininger,Medical Univeristy of Vienna; Christof Jungbauer, Austrian Red Cross; Volker Witt, St. Anna Children's Hospital; Hedda Wardemann, German Cancer Research Center (DKFZ); Florian Halbritter, Children's Cancer Research Insitute (CCRI); Matthias Farlik-Födinger, Medical Univeristy of Vienna)
(In collaboration with: Josef Penninger, University of British Columbia, IMBA & Apeiron; Johannes Stadlmann, IMBA & University of Natural Resources and Life Sciences)
(in collaboration with: Ali Mirazimi, Karolinska Institutet; Nuria Montserrat, Institute for Bioengineering of Catalonia (IBEC), Apeiron Biologics)
The Penninger lab has made seminal discoveries in ACE2, its critical in vivo role as SARS receptor and its role in protecting multiple tissues from organ damage. RACE2 is also the critical receptor for SARS-CoV2, the cause of COVID19. Recently they have generated preliminary data that SARS-CoV2 can infect blood vessels organoids (which we can develop from human iPS cells; Wimmer et al. Nature 2019), a critical finding to understand viral spread into distant tissues. To fundamentally understand SARS-CoV2 infections of blood vessels, we now propose to generate large quantities of these vessels and study the cytotoxicity of the virus and gene expression profiles of infected blood vessels at the single cell resolution in vitro and in vivo, in the presence and absence of soluble ACE2, which is undergoing clinical testing for COVID19 patients.
Funding: € 50,000
Duration: 1 May 2020 - 31 April 2021
Contact and PI details: https://www.imba.oeaw.ac.at/research/josef-penninger/
(in Kooperation mit Miriam Klausberger, University of Natural Resources and Life Sciences; Reingard Grabherr, University of Natural Resources and Life Sciences; Florian Grebien, Vetmeduni Vienna; Heinz Burgmann, Medical University of Vienna)
(in collaboration with: Max Perutz Labs, a Joint Venture of the Univeristy of Vienna and the Medical University of Vienna; University of Vienna; IMP; IMBA; GMI and other institutions in Vienna)
(in collaboration with: Julius Brennecke, IMBA; Andrea Pauli, IMP; Ulrich Elling, IMBA; Stefan Ameres, IMBA; Alwin Köhler, University of Vienna/VCDI; Manuela Födinger (KFJ/KAV))
(in collaboration with: Wiener Krankenanstaltenverbund, Sigmund Freud Universität)
(in collaboration with: Complexity Science Hub; dwh GmbH; SpotOn Statistics GmbH, Statistik Austria)
(in collaboration with: Richard Crevenna, Medical University of Vienna; Maren Jeleff, Medical University of Vienna; Elena Jirovsky, Medical University of Vienna)
(in collaboration with: Medical University of Vienna)
(in collaboration with: David Garcia, Complexity Science Hub (CSH) and Medical University of Vienna)
(in collaboration with: Erika Mosor, Valentin Ritschl, Maisa Omara, Martin Posch, Franz König, Matthias Wielscher and Michael Hiesmayr, Medical University of Vienna; Susanne Perkhofer, FHG Innsbruck; Michael Schirmer, Medical University of Innsbruck; Angelika Rzepka, Bernhard Pfeifer, Peter Kastner and Anton Dunzendorfer, Austrian Institute of Technology; Florian Stigler and Martin Sprenger, Medical University of Graz; Siegfried Walch and Nils Mevenkamp, Management Center Innsbruck)
(in collaboration with: Sylvia Kritzinger, University of Vienna; Hajo Boomgaarden, University of Vienna; Barbara Prainsack, University of Vienna)
(in collaboration with: Institut for Socialanthropolog Austrian Academy of Sciences)
(in collaboration with: Arbeiterkammer Wien; Frauenabteilung)
(in collaboration with: Marko Lüftenegger, University of Vienna; Christiane Spiel, University of Vienna)
(in collaboration with Fraunhofer Austria; Bundesministerium für Digitalisierung und Wirtschaftsstandort; Bundeministerium für Landwirtschaft, Regionen und Tourismus; Universität Salzburg; Universität Klagenfurt)
(in collaboration with: Thomas Lindner, Jakob Müllner, Michael Wolfesberger (WU Vienna); Andreas König, Universität Passau; Oesterreichische Nationalbank (OeNB); Wirtschaftskammer Österreich (WKO))
(in cooperation with: Manfred Gronalt, Medical University of Vienna; Beate Pinior, University of Natural Resources and Life Sciences; Vetmeduni Vienna)