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Flow cytometric signal typing for therapy response prediction in pediatric myeloid leukemia
| Project type: | Research Project |
| Programme: | Life Sciences |
| Call: | Life Sciences Call 2007 |
| Start: | 01.03.2008 |
| Duration: | 4,00 years |
| Grant awarded: | 654.500 € |
| Keywords: | myeloid leukemia, children, flow cytometry, intracellular signaling, signal transduction inhibitor, prognostic marker, bcr-abl, murine disease models, leukemic stem cells |
Michael Dworzak & Veronika Sexl
St. Anna Kinderkrebsforschung, Immunological Diagnostics &
Medical University of Vienna, Institute of Pharmacology
| Project partners: | Helmut Gadner (St. Anna Kinderkrebsforschung, CCRI) Bernd Binder (Medical University of Vienna, Centre for biolmolecular medicine and pharmacology/Institute of Pharmacology) |
The rapidly expanding knowledge about the intracellular signaling pathways has
placed new small molecule compounds at the forefront of clinical research trials
in Leukemia, which either inhibit cell proliferation or activate cell death. The
conventional practice of therapy is about to radically change as a result of the
development of these new targeted agents. Yet, it is clear that a great amount of
work remains to be done to elucidate the mechanisms by which leukemic cells
respond to diverse agents and to determine the optimal settings in which patients
are bound to benefit maximally from new therapy options. This project aims at
developing methods based on flow cytometry to determine the intracellular
signaling status of individual leukemic cells to identify useful therapy options and
monitor treatment in leukemic patients.
